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Effects of long-term benzodiazepine use may include disinhibition, impaired concentration and memory, depression, [19] [20] as well as sexual dysfunction. [6] [21] The long-term effects of benzodiazepines may differ from the adverse effects seen after acute administration of benzodiazepines. [22]
Flumazenil is a benzodiazepine receptor antagonist that can reverse the effects of benzodiazepines, although its use following benzodiazepine overdose is controversial. Medical observation and supportive care are the mainstay of treatment of benzodiazepine overdose. [16]
Benzodiazepines share a similar chemical structure, and their effects in humans are mainly produced by the allosteric modification of a specific kind of neurotransmitter receptor, the GABA A receptor, which increases the overall conductance of these inhibitory channels; this results in the various therapeutic effects as well as adverse effects ...
In rare cases, people taking escitalopram may be advised to take a benzodiazepine along with the medication for the first few weeks, as benzodiazepines can help reduce the early adverse effects of ...
A study into the effects of the benzodiazepine receptor antagonist, flumazenil, on benzodiazepine withdrawal symptoms persisting after withdrawal was carried out by Lader and Morton. Study subjects had been benzodiazepine-free for between one month and five years, but all reported persisting withdrawal effects to varying degrees.
Benzodiazepine use disorder (BUD), also called misuse or abuse, [1] is the use of benzodiazepines without a prescription and/or for recreational purposes, which poses risks of dependence, withdrawal and other long-term effects.
It’s personal, and some people will naturally be more sensitive to side effects than others, like they would with any other medication, says Dr. Gold. ... (like benzodiazepines, for example) and ...
Lorazepam appears to have more profound adverse effects on memory than other benzodiazepines; it impairs both explicit and implicit memory. [58] [59] In the elderly, falls may occur as a result of benzodiazepines. Adverse effects are more common in the elderly, and they appear at lower doses than in younger people.