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Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene.PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
Here’s an overview of what PSA test results mean and the next steps if your levels are high. What Your PSA Test Results Mean. ... Dr. Levin says. Treatments can include surgery, radiation or ...
It causes a dramatic reduction in PSA levels and tumor sizes in aggressive advanced-stage prostate cancer for 70% of patients. [47] [48] Chemotherapy may be offered to slow disease progression and postpone symptoms. The most commonly used regimen combines the chemotherapeutic drug docetaxel with a corticosteroid such as prednisone.
After either treatment, PSA levels are monitored regularly. Up to half of those treated will eventually have a rise in PSA levels, suggesting the tumor or small metastases are growing again. [54] People with high or rising PSA levels are often offered another round of radiation therapy directed at the former tumor site.
“Elevated PSA levels can be an indicator of prostate issues, including cancer,” Dr. Spratt. ... PSA levels between 4 and 10 suggest you could have about a 25 percent chance of prostate cancer ...
The reduction in testosterone levels that occurs during GnRH antagonist therapy subsequently reduces the size of the prostate cancer. This in turn results in a reduction in prostate-specific antigen (PSA) levels in the patient's blood and so measuring PSA levels is a way to monitor how patients with prostate cancer are responding to treatment ...
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