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A pineal gland cyst is a usually benign (non-malignant) cyst in the pineal gland, a small endocrine gland in the brain. Historically, these fluid-filled bodies appeared on 1-4% of magnetic resonance imaging (MRI) brain scans, but were more frequently diagnosed at death, seen in 4-11% of autopsies. [1]
Intermittency of symptoms is characteristic of this lesion. [2] Untreated pressure caused by these cysts can result in brain herniation. [3] Colloid cyst symptoms have been associated with four variables: cyst size, cyst imaging characteristics, ventricular size, and patient age.
Symptomatic (producing or showing symptoms) cysts may require surgical removal if they are present in areas where brain damage is unavoidable, or if they produce chronic symptoms disruptive to the quality of life of the patient. Some examples of cyst removal procedures include: permanent drainage, fenestration, and endoscopic cyst fenestration. [3]
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Lesion network mapping is a neuroimaging technique that analyzes the connectivity pattern of brain lesions to identify neuroanatomic correlates of symptoms. [1] [2] [3] The technique was developed by Michael D. Fox and Aaron Boes to understand the network anatomy of lesion induced neurologic and psychiatric symptoms that can not be explained by focal anatomic localization.
MRI scans showing hyperintensities. A hyperintensity or T2 hyperintensity is an area of high intensity on types of magnetic resonance imaging (MRI) scans of the brain of a human or of another mammal that reflect lesions produced largely by demyelination and axonal loss.
Patients with arachnoid cysts may never show symptoms, even in some cases where the cyst is large. Therefore, while the presence of symptoms may provoke further clinical investigation, symptoms independent of further data cannot—and should not—be interpreted as evidence of a cyst's existence, size, location, or potential functional impact on the patient.
The presence of neurofibrillary tangles in the brain is one of the key hallmarks of Alzheimer’s disease. These irregular clumps of protein are closely associated with disease progression.
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