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The most common side effects of metformin include: Diarrhea. Nausea. Vomiting. Upset stomach. Weakness. ... However, if you have a long morning commute or work at an office, you might want to take ...
Diarrhea is a well-known side effect of metformin. Learn more about why this gut-related side effect happens and how to manage it. Skip to main content. 24/7 Help. For premium support please call: ...
How long does it take for metformin to work? For type 2 diabetes and PCOS, metformin typically starts working within 48 hours of the first dose, says Dr. Wheeler.
Metformin inhibits cyclic AMP production, blocking the action of glucagon, and thereby reducing fasting glucose levels. [117] Metformin also induces a profound shift in the faecal microbial community profile in diabetic mice, and this may contribute to its mode of action possibly through an effect on glucagon-like peptide-1 secretion. [108]
The most common side effect is diarrhea and dyspepsia, occurring in up to 30% of patients. The most important and serious side effect is lactic acidosis, therefore metformin is contraindicated in advanced chronic kidney disease. Kidney function should be assessed before starting metformin.
[1] [2] It is regarded as a second-line option compared to metformin, due to metformin's well-established safety and efficacy. [1] Use of glimepiride is recommended in conjunction with lifestyle modifications such as diet and exercise. [1] It is taken by mouth, [1] reaching a peak effect within three hours and lasting for about a day. [1]
At higher doses in particular, it can cause an upset stomach, nausea and diarrhea. However, most people tolerate it well, especially by going to a lower dose and building back up, says Thangudu.
If your diarrhea lasts longer than a couple of days, Dr. Ahmad suggests calling your doctor, especially if you also have a fever, dehydration, bloody stool, weight loss, pain, and severe pain.