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2. Lesch–Nyhan syndrome - Wikipedia

   en.wikipedia.org/wiki/Lesch–Nyhan_syndrome

   The drug allopurinol is utilized to stop the conversion of oxypurines into uric acid, and prevent the development of subsequent arthritic tophi (produced after having chronic gout), kidney stones, and nephropathy, the resulting kidney disease. Allopurinol is taken orally, at a typical dose of 3–20 mg/kg per day.

3. Gout - Wikipedia

   en.wikipedia.org/wiki/Gout

   Gout (/ ɡ aʊ t / GOWT [7]) is a form of inflammatory arthritis characterized by recurrent attacks of pain in a red, tender, hot, and swollen joint, [2] [8] caused by the deposition of needle-like crystals of uric acid known as monosodium urate crystals. [9]

4. Uric acid - Wikipedia

   en.wikipedia.org/wiki/Uric_acid

   Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C 5 H 4 N 4 O 3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of purine nucleotides, and it is a normal component of urine. [1]

5. Hypoxanthine-guanine phosphoribosyltransferase - Wikipedia

   en.wikipedia.org/wiki/Hypoxanthine-guanine...

   Mutations in the gene lead to hyperuricemia.At least 67 disease-causing mutations in this gene have been discovered: [5] Some men have partial (up to 20% less activity of the enzyme) HGPRT deficiency that causes high levels of uric acid in the blood, which leads to the development of gouty arthritis and the formation of uric acid stones in the urinary tract.

6. Allopurinol - Wikipedia

   en.wikipedia.org/wiki/Allopurinol

   Allopurinol is used to reduce urate formation in conditions where urate deposition has already occurred or is predictable. The specific diseases and conditions where it is used include gouty arthritis, skin tophi, kidney stones, idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate ...

7. Crystal arthropathy - Wikipedia

   en.wikipedia.org/wiki/Crystal_arthropathy

   accumulation of uric acid: negative Chondrocalcinosis [3] aka Pseudogout: ... otherwise you can cause an acute flare/worsening of the gout. However, they are already ...