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The optic disc appears abnormally small, because not all the optic nerve axons have developed properly. [1] It is often associated with endocrinopathies (hormone deficiencies), developmental delay, and brain malformations. [2] The optic nerve, which is responsible for transmitting visual signals from the retina to the brain, has approximately 1 ...
In 1941 Dr. David Reeves at the Children's Hospital Los Angeles described an association between underdevelopment of the optic nerve with an absent septum pellucidum. Fifteen years later French doctor Georges de Morsier reported his theory that the two abnormalities were connected and coined the term septo-optic dysplasia.
The optic nerve can be damaged when exposed to direct or indirect injury. Direct optic nerve injuries are caused by trauma to the head or orbit that crosses normal tissue planes and disrupts the anatomy and function of the optic nerve; e.g., a bullet or forceps that physically injures the optic nerve.
The optic tract is a continuation of the optic nerve that relays information from the optic chiasm to the ipsilateral lateral geniculate nucleus (LGN), pretectal nuclei, and superior colliculus. [14] The optic tract represents the first stage in the visual pathway in which visual information is transferred in a homonymous nature. [ 15 ]
Amsler grid, Chart 1. There are 7 types of Amsler grid charts. All charts measure 10 cm × 10 cm (3.9 in × 3.9 in), which when viewed at a distance of 33 cm (13 in) from the eye can be used to measure defects in the central 20 degrees of the visual field. [3]
Dominant optic atrophy was first described clinically by Batten in 1896 and named Kjer’s optic neuropathy in 1959 after Danish ophthalmologist Poul Kjer, who studied 19 families with the disease. [3] Although dominant optic atrophy is the most common autosomally inherited optic neuropathy (i.e., disease of the optic nerves), it is often ...
Ocular disc dysplasia is the most notable ocular defect of the disease. An abnormal development in the optic stalk causes optic disc dysplasia, which is caused by a mutation in the Pax2 gene. [4] The nerve head typically resembles the morning glory disc anomaly, but has also been described as a coloboma. [4]
The exact mechanism of optic nerve ischemia in these cases remains unclear, but contributing factors may include hypotension, anemia, hypoxia, and changes in the autoregulation of optic nerve arterial blood flow. The incidence of ischemic optic neuropathy leading to vision loss following general surgeries ranges between 0.1% and 0.002%.
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