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A mineralocorticoid receptor antagonist (MRA or MCRA) [1] or aldosterone antagonist, is a diuretic drug which antagonizes the action of aldosterone at mineralocorticoid receptors. This group of drugs is often used as adjunctive therapy, in combination with other drugs, for the management of chronic heart failure .
Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. [4] [5] It is essential for sodium conservation in the kidney, salivary glands, sweat glands, and colon. [6]
The mineralocorticoid receptor (or MR, MLR, MCR), also known as the aldosterone receptor or nuclear receptor subfamily 3, group C, member 2, (NR3C2) is a protein that in humans is encoded by the NR3C2 gene that is located on chromosome 4q31.1-31.2. [5] MR is a receptor with equal affinity for mineralocorticoids and glucocorticoids.
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The epithelial sodium channel (ENaC), (also known as amiloride-sensitive sodium channel) is a membrane-bound ion channel that is selectively permeable to sodium ions (Na +).It is assembled as a heterotrimer composed of three homologous subunits α or δ, β, and γ, [2] These subunits are encoded by four genes: SCNN1A, SCNN1B, SCNN1G, and SCNN1D.
BEIJING (Reuters) -China accused the Philippines on Friday of having "provoked trouble" in the South China Sea with U.S. backing, a week after Beijing and Manila traded accusations over a new ...
Bilyonaryo News Channel, otherwise known as BNC, is a Philippine free-to-air and pay television news channel based in Quezon City, Philippines and it is currently owned by the Prage Management Corporation, the company behind business news website Bilyonaryo and other media platforms including Politiko and Abante.
Police in the Philippines are investigating reports that kidnapped American YouTuber Elliot Eastman has been shot dead. Eastman, 26, was reportedly shot twice while resisting an abduction by ...