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Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body. [ 1 ][ 7 ][ 2 ] One nanogram per millilitre (1 ng/mL) is equivalent to 2.5 nanomoles per litre (2.5 nmol/L). Severe deficiency: < 12 ng/mL = < 30 nmol/L[ 2 ...
Vitamin D insufficiency, on the other hand, is characterized by a blood 25(OH)D level between 12–20 ng/mL (30–50 nmol/liter). [2] [25] It is estimated that one billion adults worldwide are either vitamin D insufficient or deficient, including those in developed countries across Europe. [26]
proteins. 25-Hydroxyvitamin D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase[ 5 ] or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene. [ 6 ][ 7 ][ 8 ] VD 1A hydroxylase is located in the proximal tubule of the kidney and a ...
Calcitriol was identified as the active form of vitamin D in 1971 and the drug was approved for medical use in the United States in 1978. [7] It is available as a generic medication . [ 12 ] In 2021, it was the 258th most commonly prescribed medication in the United States, with more than 1 million prescriptions.
Ergocalciferol may be used as a vitamin D supplement, whereas cholecalciferol (vitamin D 3) is produced naturally by the skin when exposed to ultraviolet light. [15] Ergocalciferol (D 2 ) and cholecalciferol (D 3 ) are considered to be equivalent for vitamin D production, as both forms appear to have similar efficacy in ameliorating rickets ...
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Cholecalciferol is a form of vitamin D which is naturally synthesized in skin and functions as a pro-hormone, being converted to calcitriol. This is important for maintaining calcium levels and promoting bone health and development. [ 4 ] As a medication, cholecalciferol may be taken as a dietary supplement to prevent or to treat vitamin D ...