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An unusual guide snoRNA U85 that functions in both 2′-O-ribose methylation and pseudouridylation of small nuclear RNA (snRNA) U5 has been identified. [14] This composite snoRNA contains both C/D and H/ACA box domains and associates with the proteins specific to each class of snoRNA (fibrillarin and Gar1p, respectively).
2'-O-methylation (2'-O-Me) is a common nucleotide epitranscriptomics modification of ribosomal RNA (rRNA). The rRNA is transcribed from DNA and then used to create proteins through translation. [ 1 ] The resulting protein would normally be solely dependent on the gene it was translated from, but the methylation of the RNA would influence the ...
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U25 is found in gene clusters in plants [2] and within the U22 snoRNA host gene (UHG) in mammals. [3] U25 is thought to as a 2'-O-ribose methylation guide for ribosomal RNA. This RNA has also been named snoRNA R73 in some plants.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] [2] In humans U29 and several other snoRNAs (U22 and U25-U31) are located in the introns of the same gene (called UHG for U22 host gene). [3] [4] U29 is proposed to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA ...
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] [2] U53 was originally cloned from HeLa cells and is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) at residue C3848. [3] [4] It is related to mouse snoRNA MBII-35 [5]
This family functions to direct site-specific 2'-O-methylation of substrate RNAs. [1] This snoRNA was originally cloned from human HeLa cells during a screen for intron encoded snoRNAs. [2] It is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) at residue A99 3
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] This snoRNA was originally cloned from HeLa cells and expression verified by northern blotting. [2] It is predicted to guide 2'O-ribose methylation of ribosomal RNA (rRNA) 28S at residue C3866.
Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs. [1] U32 is encoded within intron 2 of the ribosomal protein L13 gene in human and mouse [2] and is predicted to guide the 2'O-ribose methylation of both 18S ribosomal RNA (rRNA) residue G1328 and 28S rRNA residue A1511.