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Peptic ulcer disease is when the inner part of the stomach's gastric mucosa (lining of the stomach), the first part of the small intestine, or sometimes the lower esophagus, gets damaged.
The gastric folds consist of two layers: Mucosal layer – This layer releases stomach acid.It is the innermost layer of the stomach. [5] It is affected by the hormone histamine, which signals it to release hydrochloric acid (HCl).