Search results
Results from the WOW.Com Content Network
A well studied model is celiac disease, in which increased intestinal permeability appears secondary to the abnormal immune reaction induced by gluten and allows fragments of gliadin protein to get past the intestinal epithelium, triggering an immune response at the intestinal submucosa level that leads to diverse gastrointestinal or extra ...
The intestinal epithelium is the single cell layer that forms the luminal surface (lining) of both the small and large intestine (colon) of the gastrointestinal tract. Composed of simple columnar epithelium its main functions are absorption, and secretion.
Refractory coeliac disease should not be confused with the persistence of symptoms despite gluten withdrawal [115] caused by transient conditions derived from the intestinal damage, [112] [113] [116] which generally revert or improve several months after starting a gluten-free diet, [117] [118] such as small intestinal bacterial overgrowth ...
Altered intestinal barrier function may play a role in the development of celiac disease. By allowing gliadin, the causative agent of celiac disease, to cross the intestinal barrier, inappropriate activation of the immune system can occur. Celiac disease sufferers have been shown to have elevated intestinal permeability and altered tight junctions.
These lymphocytes may also infiltrate and disrupt the architecture of nearby intestinal crypts and the epithelial lining. Unlike celiac disease-associated EATL, the lesions usually have little evidence of inflammatory cells (particularly lymphoplasmacytoid cells, i.e. cells showing a mixture of B cell and plasma cell morphological features) or ...
Involves in epithelial cell maturation as well as goblet and Paneth cell differentiation. Required for the small intestinal identity during development. In IEC-6 cells, conditional expression induced enterocyte and goblet like cells: 21081128 [13] 19386267 [14] 8552090 [15] CTNNB1: Catenin, beta: Paneth cell differentiation.
germinal epithelium (female) reproductive - female: fallopian tubes: Simple columnar, ciliated - reproductive - female: endometrium : Simple columnar, ciliated - reproductive - female: cervix : Simple columnar - reproductive - female: cervix : Stratified squamous, non-keratinized - reproductive - female: vaginal epithelium
In Type II RCD, the same types of abnormal ILE found in the small intestine may be detected in the colon, stomach, [9] mesenteric lymph nodes, blood, bone marrow, and epithelium of the airways and skin. [9] Finally, the small intestinal lesions in Type II RCD contain IL-2 and IL-21 [18] as well as increased levels of IL-15. [3]