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Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
This condition was first discovered in 1995 by Melberg et al. when they described 5 members of a 4-generation Swedish family where cerebellar ataxia and sensorineural deafness presented as an autosomal dominant trait, 4 of them had narcolepsy and 2 had diabetes mellitus. The oldest members had psychiatric symptoms, neurological anomalies, and ...
Narcolepsy with cataplexy is considered an autoimmune-mediated disorder, so some therapies based on this hypothesis have been developed. Immunological therapies developed include: [ 20 ] Corticosteroids : after testing in 1 human and 1 canine case it proved to be ineffective so is less likely to be further used.
A series of more advanced designs were introduced, especially through World War II, that maintained power to both tracks during steering, a concept known as regenerative steering. Some also allowed one track to move forward while the other reversed, allowing the tank to spin in place, a concept known as neutral steering. The first really ...
Marles steering gear was an hour-glass-and-roller steering gear for mechanically propelled vehicles invented by British inventor and businessman Henry Marles (1871-1955) who also gave his name to his joint-venture Ransome & Marles a major British ball-bearing manufacturer. Aside from ease of use Marles' steering's great appeal to drivers was ...
Pediatric narcolepsy cases are cases when patients are diagnosed or experience symptoms onset for narcolepsy before the age of 18. Of patients who obtain a formal diagnosis for narcolepsy, more than 50% report first experiencing symptoms of narcolepsy more than 10 years before their formal diagnosis, with an average age of symptom onset being at age 15 and symptom onset most likely to occur ...
Power steering is a system for reducing a driver's effort to turn a steering wheel of a motor vehicle, by using a power source to assist steering. [1]Hydraulic or electric actuators add controlled energy to the steering mechanism, so the driver can provide less effort to turn the steered wheels when driving at typical speeds, and considerably reduce the physical effort necessary to turn the ...
Ilmor was heavily criticized when four of its NT1 engines failed during the 2019 World of Westgate 200 at Las Vegas Motor Speedway, effectively eliminating ThorSport Racing drivers Grant Enfinger and Johnny Sauter from the playoffs. Matt Crafton also experienced an engine failure during the race, but survived the playoffs due to his points ...