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  2. Histamine receptor - Wikipedia

    en.wikipedia.org/wiki/Histamine_receptor

    H1 receptors are linked to allergic responses, H2 to gastric acid regulation, H3 to neurotransmitter release modulation, and H4 to immune system function. There are four known histamine receptors: H 1 receptor H1 Receptors: These receptors are primarily located on smooth muscle cells, endothelial cells, and neurons.

  3. H1 antagonist - Wikipedia

    en.wikipedia.org/wiki/H1_antagonist

    Spacer between the central X and the amine, usually 2–3 carbons in length, linear, ring, branched, saturated or unsaturated; Amine is substituted with small alkyl groups, e.g., CH 3; X = N, R1 = R2 = small alkyl groups X = C X = CO. Chirality at X can increase both the potency and selectivity for H1-receptors

  4. Antihistamine - Wikipedia

    en.wikipedia.org/wiki/Antihistamine

    [4] [5] Normally, histamine binds to the H 1 receptor and heightens the receptor's activity; the receptor antagonists work by binding to the receptor and blocking the activation of the receptor by histamine; by comparison, the inverse agonists bind to the receptor and both block the binding of histamine, and reduce its constitutive activity, an ...

  5. Histamine H2 receptor - Wikipedia

    en.wikipedia.org/wiki/Histamine_H2_receptor

    H 2 receptors are a type of histamine receptor found in many parts of the anatomy of humans and other animals. They are positively coupled to adenylate cyclase via G s alpha subunit . It is a potent stimulant of cAMP production, which leads to activation of protein kinase A . [ 5 ]

  6. Histamine H1 receptor - Wikipedia

    en.wikipedia.org/wiki/Histamine_H1_receptor

    The H 1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. This receptor is activated by the biogenic amine histamine . It is expressed in smooth muscles , on vascular endothelial cells , in the heart, and in the central nervous system .

  7. H2 receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/H2_receptor_antagonist

    Ball-and-stick model of cimetidine, the prototypical H 2 receptor antagonist. H 2 antagonists, sometimes referred to as H2RAs [1] and also called H 2 blockers, are a class of medications that block the action of histamine at the histamine H 2 receptors of the parietal cells in the stomach. This decreases the production of stomach acid.

  8. 26-year-old California man mauled by his 3 dogs; animals ...

    www.aol.com/news/26-old-california-man-mauled...

    A second victim was taken to the hospital for "serious bite injuries," according to the San Diego Humane Society.

  9. Drug action - Wikipedia

    en.wikipedia.org/wiki/Drug_action

    There are also different subtypes of receptor which elicit different effects in response to the same agonist. For example, there are two types of histamine receptor: H1 and H2. Activation of the H1 subtype receptor causes contraction of smooth muscle, whereas activation of the H2 receptor stimulates gastric secretion.

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