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Malignant hyperthermia is diagnosed on clinical grounds, but various laboratory investigations may prove confirmatory. These include a raised creatine kinase level, elevated potassium, increased phosphate (leading to decreased calcium) and—if determined—raised myoglobin; this is the result of damage to muscle cells.
Malignant hyperthermia is a rare complication of some types of general anesthesia. Hyperthermia can also be caused by a traumatic brain injury. [4] [5] [6] Hyperthermia differs from fever in that the body's temperature set point remains unchanged.
Harrison experimentally induced malignant hyperthermia with halothane anesthesia in genetically susceptible pigs, and obtained an 87.5% survival rate, where seven of his eight experiments survived after intravenous administration of dantrolene.
Hyperthermia therapy (or hyperthermia, or thermotherapy) is a type of medical treatment in which body tissue is exposed to temperatures above body temperature, in the region of 40–45 °C (104–113 °F). Hyperthermia is usually applied as an adjuvant to radiotherapy or chemotherapy, to which it works as a sensitizer, in an effort to treat cancer.
Stowell is best-known publicly for her work on malignant hyperthermia (MH), a genetic disorder which causes a severe and potentially fatal hypermetabolic reaction in susceptible people when exposed to inhaled anaesthetics or the muscle relaxant suxamethonium. Malignant hyperthermia has an incidence of between 1:10,000 and 1:250,000 worldwide ...
The rationale for this approach is the simultaneous utilization of three different antineoplastic strategies: surgical resection, chemotherapy, and hyperthermia. The goal of surgical cytoreduction is to remove all gross disease including tumors that are in resectable areas of the lung or other structures and any large pleural nodules.
Hyperthermic intraperitoneal chemotherapy (HIPEC) is a type of hyperthermia therapy used in combination with surgery in the treatment of advanced abdominal cancers. [1] In this procedure, warmed anti-cancer medications are infused and circulated in the peritoneal cavity (abdomen) for a short period of time.
Neuroleptic malignant syndrome; rare, life-threatening hyperpyrexia caused by antidopaminergic drugs (mostly antipsychotics) e.g. Haloperidol, Chlorpromazine Serotonin syndrome ; excessive serotonergic activity due usually to combined use of serotonergic drugs ( e.g. antidepressants , stimulants , triptans )