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Molecules with a polar surface area of greater than 140 angstroms squared (Å 2) tend to be poor at permeating cell membranes. [1] For molecules to penetrate the blood–brain barrier (and thus act on receptors in the central nervous system), a PSA less than 90 Å 2 is usually needed. [2] TPSA is a valuable tool in drug discovery and development.
On the one hand, the large size of common devices is due to the large distance needed between the sample and the detectors to provide the desired angular resolution. Furthermore, their high price is mainly due to the use of expensive laser sources and a large number of detectors, i.e., one sensor for each scattering angle to be monitored.
From these, it is easy to calculate the area (in cm 2) of the aortic valve by simply dividing the LV stroke volume (in cm 3) by the AV VTI (in cm) measured on the spectral Doppler display using continuous-wave Doppler. [citation needed] Stroke volume = 0.785(π/4) x Diameter 2 x VTI of LVOT Cross sectional area of LVOT = 0.785(π/4) x LVOT ...
In fluid dynamics, Sauter mean diameter (SMD) is an average measure of particle size. It was originally developed by German scientist Josef Sauter in the late 1920s. [1] [2] It is defined as the diameter of a sphere that has the same volume/surface area ratio as a particle of interest. Several methods have been devised to obtain a good estimate ...
The surface-area-to-volume ratio has physical dimension inverse length (L −1) and is therefore expressed in units of inverse metre (m-1) or its prefixed unit multiples and submultiples. As an example, a cube with sides of length 1 cm will have a surface area of 6 cm 2 and a volume of 1 cm 3. The surface to volume ratio for this cube is thus
VO2 max is a measure of how much oxygen your body absorbs and uses while you work out. (V stands for “volume” while “O2” is for oxygen.) (V stands for “volume” while “O2” is for ...
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