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  2. Apixaban - Wikipedia

    en.wikipedia.org/wiki/Apixaban

    The results of the negotiations were announced in August 2024, and Medicare's negotiated price for a 30-day supply of Eliquis is $231, a 56% decrease from the 2023 list price of $521. [42] The pricing is set to take effect in 2026. [43] [44]

  3. Drug packaging - Wikipedia

    en.wikipedia.org/wiki/Drug_packaging

    The primary component of a blister pack is a cavity or pocket made from a thermoformed plastic. This usually has a backing of paperboard or a lidding seal of aluminum foil or plastic film . Blister packs are useful for protecting drugs against external factors, such as humidity and contamination for extended periods of time.

  4. Discovery and development of direct Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Discovery_and_development...

    Another natural occurring direct Xa-inhibitor, the tick anticoagulant peptide (TAP), was discovered in 1990. It is a single-chain, 60 amino acid peptide and like antistasin it is a slow, tight-binding inhibitor with a similar Ki value (~0.6 nM). These two proteins were mostly used to validate factor Xa as a drug target.

  5. Dosage form - Wikipedia

    en.wikipedia.org/wiki/Dosage_form

    A combination drug (or fixed-dose combination; FDC) is a product that contains more than one active ingredient (e.g., one tablet, one capsule, or one syrup with multiple drugs). In naturopathy, dosages can take the form of decoctions and herbal teas, in addition to the more conventional methods mentioned above.

  6. Supply chain optimization - Wikipedia

    en.wikipedia.org/wiki/Supply_chain_optimization

    Typically, supply-chain managers aim to maximize the profitable operation of their manufacturing and distribution supply chain. This could include measures like maximizing gross margin return on inventory invested (balancing the cost of inventory at all points in the supply chain with availability to the customer), minimizing total operating expenses (transportation, inventory and ...

  7. Anticoagulant - Wikipedia

    en.wikipedia.org/wiki/Anticoagulant

    An anticoagulant, commonly known as a blood thinner, is a chemical substance that prevents or reduces the coagulation of blood, prolonging the clotting time. [1] Some occur naturally in blood-eating animals, such as leeches and mosquitoes, which help keep the bite area unclotted long enough for the animal to obtain blood.

  8. Supply chain management - Wikipedia

    en.wikipedia.org/wiki/Supply_chain_management

    A supply chain is the network of all the individuals, organizations, resources, activities and technology involved in the creation and sale of a product. A supply chain encompasses everything from the delivery of source materials from the supplier to the manufacturer through to its eventual delivery to the end user.

  9. Bullwhip effect - Wikipedia

    en.wikipedia.org/wiki/Bullwhip_effect

    The first theories focusing onto the bullwhip effect were mainly focusing on the irrational behavior of the human in the supply chain, highlighting them as the main cause of the bullwhip effect. Since the 90's, the studies evolved, placing the supply chain's misfunctioning at the heart of their studies abandoning the human factors. [5]

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