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Lugol's iodine is a liquid made up of two parts potassium iodide for every one part elemental iodine in water. [8] Lugol's iodine was first made in 1829 by the French physician Jean Lugol. [7] [8] It is on the World Health Organization's List of Essential Medicines. [9] [10] Lugol's iodine is available as a generic medication and over the ...
Tincture of iodine: iodine in ethanol, or iodine and sodium iodide in a mixture of ethanol and water. Lugol's iodine: iodine and iodide in water alone, forming mostly triiodide. Unlike tincture of iodine, Lugol's iodine has a minimised amount of the free iodine (I 2) component. Iodine glycerin, a preparation used in dentistry.
In 1923 the American physician Henry Stanley Plummer discovered that high-dose iodine may be effective in the treatment of Graves’ disease. [2] [3] Today, “Plummering”, i.e. therapy with Lugol's iodine solution, is one of several emergency measures in the management of severe thyrotoxicosis. [4]
Alcohol is 50 mL, and the balance is purified water. This "2% free iodine" solution has 0.08 mol/L of I 2, which provides about 1 mg of free iodine per 0.05 mL drop. The "2% free iodine" description is based on the quantity of elemental iodine, not sodium/potassium iodide. [citation needed] USP Strong Iodine Tincture is defined in the NF as ...
But free iodine, even in Lugol's, is not safe in certain concentrations and quantities. Yes, the dose makes the poison, but a 2-3 grams of free iodine (100-150 mL of 2% Lugol's) would presumably have severe toxicity, even lethality. 10 mL at 5% (representing about 500 mg free iodine) can burn mucosa in the stomach. . Lower doses and ...
[17] [16] Potassium iodide can be administered as tablets or as Lugol's iodine solution. [16] The same dosage is recommended by the US Food and Drug Administration. [18] A single daily dose is typically sufficient for 24-hour protection. [16] However, in cases of prolonged or repeated exposure, health authorities may recommend multiple daily ...
Only the Wolff–Chaikoff effect is helpful to prevent the thyroid from uptaking radioactive iodine in the case of nuclear emergencies. Therefore, "plummering" with high-dose iodine is only effective in a short time window after the release of radionuclides. [15] Wrong timing of iodine use may even increase the risk by triggering the Plummer ...
This allows Lugol's iodine to be produced in strengths varying from 2% to 15% iodine. Elemental iodine (I 2) is poisonous if taken orally in large amounts; 2–3 grams is a lethal dose for an adult human. [71] [72] Iodine vapor is very irritating to the eye, to mucous membranes, and in the respiratory tract. Concentration of iodine in the air ...
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