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Leflunomide, sold under the brand name Arava among others, is an immunosuppressive disease-modifying antirheumatic drug , [8] used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. [9] Bottle of Leflunomide (Arava) and tablet
csDMARDs are the traditional drugs (such as methotrexate, sulfasalazine, leflunomide, hydroxychloroquine, gold salts) tsDMARDs are drugs that were developed to target a particular molecular structure; biological (bDMARD) can be further separated into original and biosimilar DMARDs (boDMARDs and bsDMARDs)
Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Leflunomide. PubMed provides review articles from the past five years (limit to free review articles)
This is considered a simple structural modification and a technically simple one-step synthetic transformation. Upon oral administration of leflunomide in vivo, the isoxazole ring of leflunomide is opened and teriflunomide is formed. [15] Teriflunomide is the only active metabolite of leflunomide, completely responsible for its therapeutic actions.
The Indonesian Food and Drug Authority (Indonesian: Badan Pengawas Obat dan Makanan, lit. 'Food and Drug Supervisory Agency'), Badan POM/BPOM, or Indonesian FDA is a government agency of Indonesia responsible for protecting public health through the control and supervision of prescription and over-the-counter pharmaceutical drugs (medication), vaccines, biopharmaceuticals, dietary supplements ...
The Indonesian Wikipedia (Indonesian: Wikipedia bahasa Indonesia, WBI for short) is the Indonesian language edition of Wikipedia. It is the fifth-fastest-growing Asian-language Wikipedia after the Japanese, Chinese, Korean, and Turkish language Wikipedias. It ranks 25th in terms of depth among Wikipedias.
Description: Skeletal formula of leflunomide.Created using ACD/ChemSketch 12.0 and Inkscape.Optimized with vim.: Date: 16 October 2010: Source: Own work, after ...
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