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  2. Thyrotropin receptor - Wikipedia

    en.wikipedia.org/wiki/Thyrotropin_receptor

    The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins [5] and is coupled to the G s protein. [6] It is primarily found on the surface of the thyroid epithelial cells, but also found on adipose tissue and fibroblasts. The latter explains the reason of the myxedema finding during Graves disease.

  3. Thyroid-stimulating hormone - Wikipedia

    en.wikipedia.org/wiki/Thyroid-stimulating_hormone

    Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, or abbreviated TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T 4), and then triiodothyronine (T 3) which stimulates the metabolism of almost every tissue in the body. [1]

  4. Antithyroid autoantibodies - Wikipedia

    en.wikipedia.org/wiki/Antithyroid_autoantibodies

    The thyrotropin receptor (TSH receptor) is the antigen for TSH receptor antibodies (TRAbs). It is a seven transmembrane G protein-coupled receptor that is involved in thyroid hormone signalling. TRAbs are grouped depending on their effects on receptor signalling; activating antibodies (associated with hyperthyroidism), blocking antibodies ...

  5. Hypothalamic–pituitary–thyroid axis - Wikipedia

    en.wikipedia.org/wiki/Hypothalamic–pituitary...

    The TSH, in turn, stimulates the thyroid to produce thyroid hormone until levels in the blood return to normal. Thyroid hormone exerts negative feedback control over the hypothalamus as well as anterior pituitary, thus controlling the release of both TRH from hypothalamus and TSH from anterior pituitary gland.

  6. Thyroid hormone receptor - Wikipedia

    en.wikipedia.org/wiki/Thyroid_hormone_receptor

    The thyroid hormone receptor (TR) [1] is a type of nuclear receptor that is activated by binding thyroid hormone. [2] TRs act as transcription factors , ultimately affecting the regulation of gene transcription and translation .

  7. Thyrotropin-releasing hormone - Wikipedia

    en.wikipedia.org/wiki/Thyrotropin-releasing_hormone

    Thyrotropin-releasing hormone (TRH) is a hypophysiotropic hormone produced by neurons in the hypothalamus that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans. [1]

  8. Thyrotropic cell - Wikipedia

    en.wikipedia.org/wiki/Thyrotropic_cell

    TRH binds to a class A G protein-coupled receptor on the surface of a thyrotropic cell, which is known as the thyrotropin-releasing hormone receptor (TRHR). Strong hydrogen bonding interactions stabilize the binding of TRH to TRHR.

  9. Thyrotropin-releasing hormone receptor - Wikipedia

    en.wikipedia.org/wiki/Thyrotropin-releasing...

    Thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds thyrotropin-releasing hormone. [5] [6] The TRHR is found on the cell membrane of thyrotropes of the anterior pituitary. When the TRHR is activated it associates with a G αq/11 protein.