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1α-Hydroxyvitamin D 5 is a chemical derivative of vitamin D 5.The motive to study 1α-hydroxyvitamin D 5 as a potential pharmaceutical drug stemmed from the tendency of calcitriol, a natural metabolite produced in the kidney, to cause toxic hypercalcemia in patients when dosed at concentrations needed to interrupt prostate cancer cells' cycle and stimulate apoptosis.
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Info Edge is an Indian technology holding company which owns, operates and invests in internet-led businesses. [6] The company's offerings include the flagship employment website Naukri.com, matrimonial website Jeevansathi.com, real estate classifieds platform 99Acres.com, and educational portal Shiksha.com, among others.
Vitamin D is a group of structurally related, fat-soluble compounds responsible for increasing intestinal absorption of calcium, magnesium, and phosphate, along with numerous other biological functions. [1] [2] In humans, the most important compounds within this group are vitamin D 3 (cholecalciferol) and vitamin D 2 (ergocalciferol). [2] [3]
Established in 1963 as Anchor Electricals Pvt. Ltd., now Panasonic Life Solutions India Pvt. Ltd. is a wholly owned subsidiary of the Panasonic Corporation of Japan. Panasonic acquired Anchor, the 50-year-old Indian family-owned electrical equipment brand, in 2007. [ 1 ]
Keane was a Boston-based Information Technology services unit of NTT DATA, itself a subsidiary of the Japanese national phone company, NTT (Nippon Telegraph and Telephone) Group. It offered Application Services, as well as Infrastructure and Business Process Outsourcing solutions delivered through onsite, nearshore, and offshore resources.
Calcifediol is strongly bound in blood by the vitamin D-binding protein. [5] Measurement of serum calcifediol is the usual test performed to determine a person's vitamin D status, to show vitamin D deficiency or sufficiency. [4] [5] Calcifediol is available as an oral medication in some countries to supplement vitamin D status. [4] [6] [7]
The Institute of Medicine in 2010 recommended a maximum uptake of vitamin D of 4000 IU/d, finding that the dose for lowest observed adverse effect level is 40,000 IU daily for at least 12 weeks, [25] and that there was a single case of toxicity above 10 000 IU after more than seven years of daily intake; this case of toxicity occurred in ...