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Dercum's disease is a rare condition characterized by multiple painful fatty tumors, called lipomas, that can grow anywhere in subcutaneous fat across the body. [1] Sometimes referred as adiposis dolorosa in medical literature, Dercum’s disease is more of a syndrome than a disease (because it has several clinically recognizable features, signs, and symptoms that are characteristic of it and ...
Adiposis dolorosa is an outdated term for many years used synonymously as Dercum's disease, lipedema or Anders disease. [1] While there are numerous references to adiposis dolorosa, it is recommended that the term no longer be used. Dercum's is now recognized as a separate condition, as is lipedema. [2] [3]
Francis Xavier Dercum (August 10, 1856 – April 24, 1931) was an American physician who first described the disease Adiposis dolorosa (also known as Dercum's disease). [1] He was a noted neurologist and specialised in treating nervous and mental disorders. [ 2 ]
Lipedema / Dercum's disease differentiation – these conditions may co-exist. Dercum's disease is a syndrome of painful growths in subcutaneous fat. Unlike lipedema, which occurs primarily in the trunk and legs, the fatty growths can occur anywhere on the body. [20] [21]
Other entities which are accompanied by multiple lipomas include Proteus syndrome, Cowden syndrome and related disorders due to PTEN gene mutations, benign symmetric lipomatosis (Madelung disease), Dercum's Disease, familial lipodystrophy, hibernomas, epidural steroid injections with epidural lipomatosis, [6] and familial angiolipomatosis.
Adiposis dolorosa (Dercum disease) is a rare condition involving multiple painful lipomas, swelling, and fatigue. Early studies mentioned prevalence in obese postmenopausal women. However, current literature demonstrates that Dercum disease is present in more women than men of all body types; the average age for diagnosis is 35 years. [20]
Dr Karen Herbst is an American endocrinologist. She is noted for her work in Dercum's Disease, lipedema, multiple symmetric lipomatosis, familial multiple lipomatosis, and angiolipomatosis at both the VA San Diego Healthcare System and University of Arizona College of Medicine in Tucson, Arizona.
Acquired generalized lipodystrophy (Lawrence syndrome, Lawrence–Seip syndrome) Adiposis dolorosa (Dercum's disease) Alpha-1 antitrypsin deficiency panniculitis (alpha1-protease deficiency panniculitis, alpha1-proteinase deficiency panniculitis) Atrophic connective tissue panniculitis