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Hydroxyethyl starch (HES/HAES), sold under the brand name Voluven among others, is a nonionic starch derivative, used as a volume expander in intravenous therapy. The use of HES on critically ill patients is associated with an increased risk of death and kidney problems.
Hydroxyethyl starch (HES/HAES, common trade names: Hespan, Voluven) is controversial. Its use in those who are very ill is associated with an increased risk of death and kidney problems. Therefore, HES/HAES is not recommended in people with known inflammatory conditions such as renal impairment. [2] [12]
Pentastarch is a subgroup of hydroxyethyl starch, with five hydroxyethyl groups out of each 11 hydroxyls, giving it approximately 50% hydroxyethylation.This compares with tetrastarch at 40% and hetastarch at 70% hydroxyethylation, respectively.
Modified starch may also be a cold-water-soluble, pregelatinized or instant starch which thickens and gels without heat, or a cook-up starch which must be cooked like regular starch. Drying methods to make starches cold-water-soluble are extrusion , drum drying , spray drying or dextrinization .
He was an advocate for the use of colloidal hydroxyethyl starch (HES) to boost blood pressure during surgery. [3] However, a meta-analysis of trials that excluded Boldt's fabricated data found that the intravenous use of hydroxyethyl starch is associated with a significant increased risk of death and acute kidney injury compared with other ...
Hydroxyethyl starch-induced pruritus is an intense itching, lasting for as long as one year, occurring following hydroxyethyl starch intravenous infusion for vascular insufficiency. [ 1 ] [ 2 ] : 401
osmotic concentration maintained by the use of metabolically inert substances like lactobionate and raffinose rather than with glucose; Hydroxyethyl starch (HES) is used to prevent edema; Substances are added to scavenge free radicals, along with steroids and insulin.
In 2012, a paper was published raising concerns regarding the use of hydroxyethyl starch in sepsis. [27] Fresenius Kabi, which makes the product, threatened legal action against the main author, Danish scientist Anders Perner. [28]