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Eukaryotic pre-mRNAs have their introns spliced out by spliceosomes made up of small nuclear ribonucleoproteins. [10] [11] In complex eukaryotic cells, one primary transcript is able to prepare large amounts of mature mRNAs due to alternative splicing. Alternative splicing is regulated so that each mature mRNA may encode a multiplicity of proteins.
In molecular biology, the five-prime cap (5′ cap) is a specially altered nucleotide on the 5′ end of some primary transcripts such as precursor messenger RNA.This process, known as mRNA capping, is highly regulated and vital in the creation of stable and mature messenger RNA able to undergo translation during protein synthesis.
On 30 October 2011, Khan addressed more than 100,000 supporters in Lahore, challenging the policies of the government, and referred to his movement as "not a flood that is coming, but a tsunami." [ 153 ] A successful public gathering of thousands of supporters was held in Karachi on 25 December 2011. [ 154 ]
Polyadenylation occurs during and/or immediately after transcription of DNA into RNA. After transcription has been terminated, the mRNA chain is cleaved through the action of an endonuclease complex associated with RNA polymerase. After the mRNA has been cleaved, around 250 adenosine residues are added to the free 3' end at the cleavage site.
The KIK-30 "Really Simple Key loader" (RASKL) is a fill device made by Sypris Electronics and approved by the US National Security Agency for the distribution of NSA Type 1 cryptographic keys. It can also store and transfer related communications security material, including control data ("load sets") for frequency hopping radios, such as ...
The .30-30 Winchester / 7.8x51mmR (officially named the .30 Winchester Center Fire or .30 WCF) cartridge was first marketed for the Winchester Model 1894 lever-action rifle in 1895. [4] The .30-30 (pronounced "thirty-thirty"), as it is most commonly known, along with the .25-35 Winchester , was offered that year as the United States' first ...
In 2000, Sathyamoorthy was an honest, disquisitive reporter who broke a story about an influential individual at a school. He tells his son, Mathimaaran, that while honesty is a virtue, cleverness is also needed to keep him and his family safe while he pursues the truth.