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  2. Maropitant - Wikipedia

    en.wikipedia.org/wiki/Maropitant

    Maropitant undergoes 1st-pass metabolism by liver enzymes, mainly CYP2D15 (which has high affinity for maropitant and clears over 90% of it) but also by the lower-affinity CYP3A12. [ 11 ] [ 12 ] Repeat dosing of maropitant eventually saturates CYP2D15, causing the drug to accumulate due to reduced clearance. [ 5 ]

  3. Hepatotoxicity - Wikipedia

    en.wikipedia.org/wiki/Hepatotoxicity

    Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval. The liver plays a central role in transforming and clearing chemicals and is susceptible to the toxicity from these agents.

  4. Elevated transaminases - Wikipedia

    en.wikipedia.org/wiki/Elevated_transaminases

    Muscle sources of the enzymes, such as intense exercise, are unrelated to liver function and can markedly increase AST and ALT. [5] Cirrhosis of the liver or fulminant liver failure secondary to hepatitis commonly reach values for both ALT and AST in the >1000 U/L range; however, many people with liver disease have normal transaminases.

  5. Enterohepatic circulation - Wikipedia

    en.wikipedia.org/wiki/Enterohepatic_circulation

    Enterohepatic circulation of drugs. Enterohepatic circulation is the circulation of biliary acids, bilirubin, drugs or other substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte and transport back to the liver.

  6. Vet-Approved Home Treatment for Senior Dogs with Arthritis - AOL

    www.aol.com/vet-approved-home-treatment-senior...

    Since not all dogs do well with the normal pain meds (like aspirin, meloxicam, etc.), you can try CBD oil. You will have to get it from the internet and follow the dosing schedule suggested by the ...

  7. Alanine transaminase - Wikipedia

    en.wikipedia.org/wiki/Alanine_transaminase

    Significantly elevated levels of ALT (SGPT) often suggest the existence of other medical problems such as viral hepatitis, diabetes, congestive heart failure, liver damage, bile duct problems, infectious mononucleosis, or myopathy, so ALT is commonly used as a way of screening for liver problems. [citation needed] Elevated ALT may also be ...

  8. Salicylate poisoning - Wikipedia

    en.wikipedia.org/wiki/Salicylate_poisoning

    Salicylate poisoning, also known as aspirin poisoning, is the acute or chronic poisoning with a salicylate such as aspirin. [1] The classic symptoms are ringing in the ears , nausea , abdominal pain , and a fast breathing rate . [ 1 ]

  9. Dad shares bittersweet video of when his 13-year-old ...

    www.aol.com/dad-shares-bittersweet-video-13...

    The best macaroni and cheese you can buy, according to Southern chefs. Food. Parade. We asked dietitians to rank 10 popular canned tunas and this was the winner. Lighter Side. Lighter Side.