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"To separate the elements (words, phrases, clauses) of a simple series of more than 2 elements, including a comma before the closing 'and' or 'or' (the so-called serial comma). Routine use of the serial comma helps to prevent ambiguity." Garner's Modern English Usage, 4th edition (Oxford University Press, 2016), "Punctuation," § D, "Comma", p. 748
This sentence is a bit different; however, a comma is necessary as well. Using commas to offset certain adverbs is optional, including then, so, yet, instead, and too (meaning also). So, that's it for this rule. or; So that's it for this rule. A comma would be appropriate in this sentence, too. or; A comma would be appropriate in this sentence too.
The difference between an Oxford comma and a regular comma is that an Oxford comma refers to the final comma in a series that would come before the last conjunction of a sentence.
Some people use the Oxford comma (also known as the Harvard or serial comma). This is a comma before "and" or "or" at the end of a series, regardless of whether it is needed for clarification purposes. For example: X, Y, and Z (with an Oxford comma) X, Y and Z (without an Oxford comma)
And note that because the comma is taking the place of a letter as opposed to serving as an opening quotation mark, it should face left. ’Tis an important spelling rule to remember! Confusing ...
If a non-quoted but otherwise identical construction would work grammatically without a comma, using a comma before a quotation embedded within a sentence is optional: The report stated "There was a 45% reduction in transmission rate." (Cf. the non-quotation The report stated there was a 45% reduction in transmission rate.)
But using double quotation marks wouldn't change the point.) Now if you aren't at all concerned with meaning, it is possible that at some level of abstract design that always putting a small base-line punctuation mark before a small high punctuation mark is aesthetically better, if there is an absolute in asethetics.
Punctuation is important, and the comma exists for a reason. Several reasons, actually. If someone has added or removed a comma in an article on your watchlist, do not simply reflexively revert the change, or edit war over it. Many commas are grammatically required, and many that aren't are stylistically preferred in formal writing.