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To induce general anesthesia, propofol is the drug used almost exclusively, having largely replaced sodium thiopental. [13]It is often administered as part of an anesthesia maintenance technique called total intravenous anesthesia, using either manually programmed infusion pumps or computer-controlled infusion pumps in a process called target controlled infusion (TCI).
An induced coma – also known as a medically induced coma (MIC), barbiturate-induced coma, or drug-induced coma – is a temporary coma (a deep state of unconsciousness) brought on by a controlled dose of an anesthetic drug, often a barbiturate such as pentobarbital or thiopental.
The paralyzing agent does not cause unconsciousness or take away the patient's ability to feel pain, but does prevent the patient from breathing, so the airway (trachea) must be protected and the lungs ventilated to ensure adequate oxygenation of the blood and removal of carbon dioxide.
Twilight anesthesia is applied to various types of medical procedures and surgeries. It is a popular choice among surgeons and doctors who are performing anything from minor plastic surgeries to dental work, and procedures that do not require extensive operations or long durations in favor of less nausea and a limited recovery period after surgery.
Called target controlled infusion (TCI), it involves using a computer-controlled syringe driver (pump) to infuse propofol throughout the duration of surgery, removing the need for a volatile anaesthetic and allowing pharmacologic principles to more precisely guide the amount of the drug used by setting the desired drug concentration.
Night time anxiety can cause you to wake up at an unusually early hour (say, 3 a.m.), feel like you haven’t had enough sleep, and then feel pressure to go back to sleep, explains Virginia Runko ...
Propofol – It is a highly lipid-soluble, GABA agonist. [15] The dosage is 1.5 mg/kg (usually 100 to 200 mg). It has quick onset of action, can cross the blood-brain barrier, wide tissue distribution, and can be hepatically cleared by the body quickly. [15] In the elderly, the rate of Propofol clearance is low.
If you drink coffee right before you nap, the caffeine will clear out the adenosine as you slumber. When you wake, you’ll feel refreshed and more alert. 5. Don’t stress if you can’t fall asleep.