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CSL Plasma is a subsidiary of its sister company CSL Behring, itself a subsidiary of CSL Limited, a biotechnology company based in Melbourne, Australia. [2] [ P 2] It is headquartered in Boca Raton, Florida, [1] and operates a total of 320 collection centers in the United States, [P 3] and a further 19 more in other nations including China, Hungary, and Germany as of 2023.
CSL was founded in 1916 as Commonwealth Serum Laboratories, an Australian government body focused on vaccine manufacture. [4] Under the first director, William Penfold, [5] CSL commenced operation in the vacant Walter and Eliza Hall Institute building at the Royal Melbourne Hospital in 1918 before moving to its purpose-built Parkville premises in the following year.
CSL Behring is a biopharmaceutical company, manufacturing plasma-derived and recombinant therapeutic products. [2] The company is a combination of Behringwerke, founded in 1904 in Marburg, Germany by Emil von Behring, and the Commonwealth Serum Laboratories (CSL), established in Australia in 1916 to provide vaccines to the people of Australia, as well as other companies acquired since 2004.
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The functions of the kidney include maintenance of acid-base balance; regulation of fluid balance; regulation of sodium, potassium, and other electrolytes; clearance of toxins; absorption of glucose, amino acids, and other small molecules; regulation of blood pressure; production of various hormones, such as erythropoietin; and activation of vitamin D.
Alpha-1 and Alpha-2 globulins are formed in the liver and play an important role in mineral transport and the inhibition of blood coagulation. [14] An example of beta globulin found in blood plasma includes low-density lipoproteins (LDL) which are responsible for transporting fat to the cells for steroid and membrane synthesis. [15]
In December 2021 CSL Limited announced it would acquire Vifor Pharma for CHF 10.9 billion (US$11.7 billion). [14] The capital raising is considered one of the ten largest secondary-market deals worldwide in 2021. [15] In August 2022 the acquisition of Vifor Pharma by Australian company CSL was completed. Vifor Pharma became CSL Vifor. [16]
In this article, all values (except the ones listed below) denote blood plasma concentration, which is approximately 60–100% larger than the actual blood concentration if the amount inside red blood cells (RBCs) is negligible.