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The use of high-dose estrogen therapy in breast cancer has mostly been superseded by antiestrogen therapy due to the improved safety profile of the latter. [17] High-dose estrogen therapy was the standard of care for the palliative treatment of breast cancer in women up to the late 1970s or early 1980s. [18
[23] [24] Estradiol should not be used in women who are pregnant or breastfeeding or who have breast cancer, among other contraindications. [20] Estradiol is a naturally occurring and bioidentical estrogen, or an agonist of the estrogen receptor, the biological target of estrogens like endogenous estradiol. [11]
"The primary treatment — and the first-line treatment — should be hormone (estrogen) therapy, especially for moderate-to-severe menopause symptoms," Dr. Anna Barbieri, assistant clinical ...
Therapy can take the form of an estrogen pill, skin patch, ring, gel, cream, or spray, and it usually includes a second hormone, progestogen, which can be either progesterone or a synthetic progestin.
The World Health Organization (WHO) does not recommend the use of combined oral contraceptive pills in women with breast cancer. [41] [97] Since combined oral contraceptive pills contain both estrogen and progestin, they are not recommended to be used in those with hormonally-sensitive cancers, including some types of breast cancer.
Women who took estrogen pills had a 14 percent higher risk of developing hypertension than those using skin patches or The post Hormone patches, creams for menopause symptoms may have lower blood ...
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