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  2. Melatonin as a medication and supplement - Wikipedia

    en.wikipedia.org/wiki/Melatonin_as_a_medication...

    Melatonin is thought to activate melatonin receptors in the suprachiasmatic nucleus of the hypothalamus to regulate the circadian clock and sleep–wake cycles. [21] When used several hours before sleep according to the phase response curve for melatonin in humans, small amounts (0.3 mg [ 56 ] ) of melatonin shift the circadian clock earlier ...

  3. Life extension - Wikipedia

    en.wikipedia.org/wiki/Life_extension

    Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled biological limit of around 125 years. [1]

  4. Melatonin - Wikipedia

    en.wikipedia.org/wiki/Melatonin

    Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.

  5. Biomedical Research & Longevity Society - Wikipedia

    en.wikipedia.org/wiki/Biomedical_Research...

    The Life Extension Foundation (LEF) was primarily funded by the sale of nutritional supplements to members of an affiliated entity, the Life Extension Buyer's Club. [citation needed] The Life Extension Buyer's Club was incorporated in Nevada, and has a separate EIN employer number than the Life Extension Foundation. Its name was changed to the ...

  6. Delayed sleep phase disorder - Wikipedia

    en.wikipedia.org/wiki/Delayed_sleep_phase_disorder

    Large doses of melatonin can even be counterproductive: Lewy et al. [48] provide support to "the idea that too much melatonin may spill over onto the wrong zone of the melatonin phase-response curve." The long-term effects of melatonin administration have not been examined. In some countries, the hormone is available only by prescription or not ...

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