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  2. Natural killer cell - Wikipedia

    en.wikipedia.org/wiki/Natural_killer_cell

    Natural killer cells, also known as NK cells, are a type of cytotoxic lymphocyte critical to the innate immune system.They are a kind of large granular lymphocytes [1] [2] (LGL), and belong to the rapidly expanding family of known innate lymphoid cells (ILC) and represent 5–20% of all circulating lymphocytes in humans. [3]

  3. KLRC2 - Wikipedia

    en.wikipedia.org/wiki/KLRC2

    KLRC2 has been shown to interact and form dimers with CD94. [5] [6] The CD94/NKG2C heterodimer can bind to HLA-E [7] [8] and this binding leads to NK cells activation.During infection with human cytomegalovirus, peptides derived from the virus are presented on HLA-E and natural killer cells that express the CD94/NKG2C receptor can specifically recognise the virus peptides.

  4. MHC class I polypeptide–related sequence A - Wikipedia

    en.wikipedia.org/wiki/MHC_class_I_polypeptide...

    MICA rather functions as a stress-induced ligand (as a danger signal) for integral membrane protein receptor NKG2D ("natural-killer group 2, member D"). MICA is broadly recognized by NK cells, γδ T cells, and CD8 + αβ T cells which carry NKG2D receptor on their cell surface and which are activated via this interaction. [7]

  5. Killer-cell immunoglobulin-like receptor - Wikipedia

    en.wikipedia.org/wiki/Killer-cell_immunoglobulin...

    Natural killer (NK) cells are a type of lymphocyte cell involved in the innate immune system's response to viral infection and tumor transformation of host cells. [20] [7] Like T cells, NK cells have many qualities characteristic of the adaptive immune system, including the production of “memory” cells that persist following encounter with antigens and the ability to create a secondary ...

  6. Adaptive NK cell - Wikipedia

    en.wikipedia.org/wiki/Adaptive_NK_cell

    An adaptive natural killer (NK) cell or memory-like NK cell is a specialized natural killer cell that has the potential to form immunological memory. [ 1 ] [ 2 ] They can be distinguished from cytotoxic NK (cNK) cells by their receptor expression profile and epigenome. [ 3 ]

  7. NCR3 - Wikipedia

    en.wikipedia.org/wiki/NCR3

    NCR3 is expressed mainly on cytoplasmic membrane of mature NK cells and functions as an activating receptor of NK cells. However it is also expressed on surface of CD8+ T cells, γδ T cells with Vδ1 TCR and ILC2. [6] [11] The presence of IL-15 stimulates the expression of NKp30+ CD8+ T cells with anti-tumor activity.

  8. Lymphokine-activated killer cell - Wikipedia

    en.wikipedia.org/wiki/Lymphokine-activated...

    In cell biology, a lymphokine-activated killer cell (also known as a LAK cell) is a white blood cell, consisting mostly of natural killer, natural killer T, and T cells that has been stimulated to kill tumor cells, but because of the function in which they activate, and the cells they can successfully target, they are classified as different than the classical natural killer and T lymphocyte ...

  9. Killer activation receptor - Wikipedia

    en.wikipedia.org/wiki/Killer_activation_receptor

    Killer Activation Receptors (KARs) are receptors expressed on the plasma membrane (cell membrane) of Natural Killer cells . KARs work together with Killer I nhibitory Receptors (abbreviated as KIRs in the text), which inactivate KARs in order to regulate the NK cells functions on hosted or transformed cells [ 1 ] .These receptors have a broad ...