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  2. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Antistasin, the first discovered naturally occurring direct Xa inhibitor Rivaroxaban, the first synthetic direct Xa inhibitor marketed as a drug Prior to the introduction of direct factor Xa inhibitors, vitamin K antagonists such as warfarin were the only oral anticoagulants for over 60 years, and together with heparin have been the main blood ...

  3. Andexanet alfa - Wikipedia

    en.wikipedia.org/wiki/Andexanet_alfa

    Andexanet alfa is used to stop life-threatening or uncontrollable bleeding in people who are taking rivaroxaban or apixaban. [8] Studies in healthy volunteers show that the molecule binds factor Xa inhibitors and counters their anti-Xa-activity. [11] The first published clinical trial was a prospective, open label, single group study. [12]

  4. Rivaroxaban - Wikipedia

    en.wikipedia.org/wiki/Rivaroxaban

    Rivaroxaban bears a striking structural similarity to the antibiotic linezolid: both drugs share the same oxazolidinone-derived core structure. [39] Accordingly, rivaroxaban was studied for any possible antimicrobial effects and for the possibility of mitochondrial toxicity , which is a known complication of long-term linezolid use. [ 40 ]

  5. Bayer's patent for blood thinner Xarelto invalid, UK ... - AOL

    www.aol.com/news/bayers-patent-blood-thinner...

    Bayer's patent covering its best-selling blood thinner Xarelto is invalid, London's High Court ruled on Friday in a blow to the German drugmaker. The company's blockbuster Xarelto drug generated ...

  6. Medication costs - Wikipedia

    en.wikipedia.org/wiki/Medication_costs

    Medication costs can be the selling price from the manufacturer, that price together with shipping, the wholesale price, the retail price, and the dispensed price. [3]The dispensed price or prescription cost is defined as a cost which the patient has to pay to get medicines or treatments which are written as directions on prescription by a prescribers. [4]

  7. Direct thrombin inhibitor - Wikipedia

    en.wikipedia.org/wiki/Direct_thrombin_inhibitor

    There are three types of DTIs, dependent on their interaction with the thrombin molecule. Bivalent DTIs (hirudin and analogs) bind both to the active site and exosite 1, while univalent DTIs bind only to the active site. [1] The third class of inhibitors, which are gaining importance recently, is the allosteric inhibitors.

  8. Template:Graph:Chart - Wikipedia

    en.wikipedia.org/wiki/Template:Graph:Chart

    A logarithmic chart allows only positive values to be plotted. A square root scale chart cannot show negative values. x: the x-values as a comma-separated list, for dates and time see remark in xType and yType; y or y1, y2, …: the y-values for one or several data series, respectively. For pie charts y2 denotes the radius of the corresponding ...

  9. Drug interaction - Wikipedia

    en.wikipedia.org/wiki/Drug_interaction

    When two drugs affect each other, it is a drugdrug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drugdrug interactions. [2] Drug interactions can be of three kinds ...