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Oxidative stress mechanisms in tissue injury. Free radical toxicity induced by xenobiotics and the subsequent detoxification by cellular enzymes (termination).. Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. [1]
Cardiotoxicity is the occurrence of heart dysfunction as electric or muscle damage, resulting in heart toxicity. [1] This can cause heart failure, arrhythmia, myocarditis, and cardiomyopathy in patients. [2] Some effects are reversible, while in others, permanent damage requiring further treatment may arise.
May Cause Alcohol Dependence “Regular or excessive alcohol consumption can lead to alcohol-related problems, including addiction, liver damage, and increased risk of certain cancers,” says ...
These toxic substances can cause oxidative stress, inflammation, and damage to the cardiomyocytes, leading to the development of ACM. [ 3 ] Additionally, chronic alcohol consumption can lead to deficiencies in essential vitamins and minerals, such as thiamine, magnesium, and selenium, which are important for the proper functioning of the heart ...
Antioxidants protect the body from the harmful effects of free radicals by bolstering cellular function and reducing oxidative stress. ... heart disease and stroke. anuwat – stock.adobe.com ...
The main pathophysiology of heart failure is a reduction in the efficiency of the heart muscle, through damage or overloading. As such, it can be caused by a wide number of conditions, including myocardial infarction (in which the heart muscle is starved of oxygen and dies), hypertension (which increases the force of contraction needed to pump blood) and cardiac amyloidosis (in which misfolded ...
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