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The most obvious, first effects (gingival and hair problems) of absence of ascorbic acid in humans come from the resulting defect in hydroxylation of proline residues of collagen, with reduced stability of the collagen molecule, causing scurvy. Increased serum and urine levels of hydroxyproline have also been demonstrated in Paget's disease. [10]
2 Human genes. 3 References. ... Printable version; In other projects ... Enzymatic synthesis of hydroxyproline from Delta1-pyrroline-3-hydroxy-5-carboxylate".
Micronutrients are nutrients such as vitamins and minerals required by organisms in varying quantities throughout life to orchestrate a range of physiological functions to maintain health. [1] [2] The following is a list of micronutrients used by various living organisms. For human-specific nutrients, see Mineral (nutrient).
Pie charts of typical human body composition by percent of mass, and by percent of atomic composition (atomic percent) Body composition may be analyzed in various ways. This can be done in terms of the chemical elements present, or by molecular structure e.g., water , protein , fats (or lipids ), hydroxyapatite (in bones), carbohydrates (such ...
Prolyl 4-hydroxylase subunit alpha-1 is an enzyme that in humans is encoded by the P4HA1 gene. [5] [6] This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the ...
Procollagen-proline dioxygenase catalyzes the following reaction: L-proline + alpha-ketoglutaric acid + O 2 → (2S, 4R)-4-hydroxyproline + succinate + CO 2. The mechanism for the reaction is similar to that of other dioxygenases, and occurs in two distinct stages: [3] In the first, a highly reactive Fe(IV)=O species is produced.
The systematic name of this enzyme class is 4-hydroxyproline 2-epimerase. Other names in common use include hydroxyproline epimerase , hydroxyproline 2-epimerase , and L-hydroxyproline epimerase . This enzyme participates in arginine and proline metabolism .
Printable version; In other projects ... This is a list of articles that describe particular biomolecules or types of biomolecules. A. For ... human chorionic ...