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Menopause occurs because of the sharp decrease of estradiol and progesterone production by the ovaries. After menopause, estrogen continues to be produced mostly by aromatase in fat tissues and is produced in small amounts in many other tissues such as ovaries, bone, blood vessels, and the brain where it acts locally. [62]
Estradiol is not produced in the gonads only; in particular, fat cells produce active precursors to estradiol, and will continue to do so even after menopause. [51] Estradiol is also produced in the brain and in arterial walls. In men, approximately 15 to 25% of circulating estradiol is produced in the testicles.
“Before menopause, the main hormone is estrogen, and after menopause, androgens like testosterone become more prevalent,” Stanhiser says. In that case, can testosterone treat menopause symptoms?
Changes in levels of estrogen-sensitive proteins after treatment with oral estradiol or oral ethinylestradiol in postmenopausal women. [68] [146] FSH is a pituitary protein and represents general/systemic estrogenic effect, while SHBG and PZP Tooltip pregnancy zone protein are hepatic proteins and represent liver estrogenic effect.
The female body has estrogen receptors almost everywhere, Garrison explains, so, as estrogen levels begin to fluctuate during perimenopause, then drop after menopause, the impacts can be far-reaching.
During menopause and perimenopause (the period of transition before menopause kicks in), women’s bodies undergo many hormonal changes. In your reproductive years, your ovaries are responsible ...
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