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In many cases, the enantiomers have distinct effects. One case is that of Propoxyphene. ... It is possible that only one of the enantiomers is active. Or, it may be ...
A racemic mixture is an equal mixture of both enantiomers, which may be easier to manufacture than a single enantiomeric form. Indacrinone Enantiomers. It is often the case that only a single one of the enantiomers contains all of the wanted bioactivity, the distomer is often less active, has no desired activity or may even be toxic. [6]
Le Bel-van't Hoff rule states that for a structure with n asymmetric carbon atoms, there is a maximum of 2 n different stereoisomers possible. As an example, D-glucose is an aldohexose and has the formula C 6 H 12 O 6. Four of its six carbon atoms are stereogenic, which means D-glucose is one of 2 4 =16 possible stereoisomers. [20] [21]
In linear form, an aldohexose has four chiral centres, which give 16 possible aldohexose stereoisomers (2 4), comprising 8 pairs of enantiomers. The linear forms of the eight D -aldohexoses, in the Fischer projection , are
An enantiopure drug is a pharmaceutical that is available in one specific enantiomeric form. Most biological molecules (proteins, sugars, etc.) are present in only one of many chiral forms, so different enantiomers of a chiral drug molecule bind differently (or not at all) to target receptors.
A non-racemic mixture of two enantiomers will have a net optical rotation. It is possible to determine the specific rotation of the mixture and, with knowledge of the specific rotation of the pure enantiomer, the optical purity can be determined. [2] optical purity (%) = [α] obs / [α] max × 100
The aldotetroses have two chiral centers (asymmetric carbon atoms) and so 4 different stereoisomers are possible. There are two naturally occurring stereoisomers, the enantiomers of erythrose and threose having the D configuration but not the L enantiomers.
Chiral auxiliaries are one of many strategies available to synthetic chemists to selectively produce the desired stereoisomer of a given compound. [4] Chiral auxiliaries were introduced by Elias James Corey in 1975 [5] with chiral 8-phenylmenthol and by Barry Trost in 1980 with chiral mandelic acid. The menthol compound is difficult to prepare ...