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The Linker for activation of T cells, also known as linker of activated T cells or LAT, is a protein involved in the T-cell antigen receptor signal transduction pathway which in humans is encoded by the LAT gene. [5] Alternative splicing results in multiple transcript variants encoding different isoforms. [6]
Epigenetics of anxiety and stress–related disorders is the field studying the relationship between epigenetic modifications of genes and anxiety and stress-related disorders, including mental health disorders such as generalized anxiety disorder (GAD), post-traumatic stress disorder, obsessive-compulsive disorder (OCD), and more.
Behavioral epigenetics is the field of study examining the role of epigenetics in shaping animal and human behavior. [1] It seeks to explain how nurture shapes nature, [2] where nature refers to biological heredity [3] and nurture refers to virtually everything that occurs during the life-span (e.g., social-experience, diet and nutrition, and exposure to toxins). [4]
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family ...
The cell then releases IL-2, which binds to its own new IL-2 receptors, causing self-stimulation and ultimately a monoclonal population of T cells. These T cells can then go on to perform effector functions such as macrophage activation, B cell activation, and cell-mediated cytotoxicity. [citation needed]
Additionally, Th17 cells in the absence of Tec kinase produced higher levels of IL-17A, IL-17F, IL-23R, and RORγt. This indicates Tec kinase could be used as a target to enhance Th17 cell function during reinfection with pathogens. [8] Tec kinase is expressed in B cells and is activated upon B-cell receptor stimulation. However, there are no B ...
Lyn is activated by stimulation of B-cell receptor, which leads to the recruitment and phosphorylation of Zap70-related nRTK, Syk. Another nRTK, Btk, is also involved in signaling mediated by the B-cell receptor. Mutations in the Btk gene are responsible for X-linked agammaglobulinemia, [2] [3] a disease characterized by the lack of mature B-cells.
T cells are grouped into a series of subsets based on their function. CD4 and CD8 T cells are selected in the thymus, but undergo further differentiation in the periphery to specialized cells which have different functions. T cell subsets were initially defined by function, but also have associated gene or protein expression patterns.