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Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. [5] The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes. [6]
CXCL10 is secreted by several cell types in response to IFN-γ.These cell types include monocytes, endothelial cells and fibroblasts. [5] CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and ...
The human interferon-gamma receptor complex consists the heterodimer of two chains: IFNGR1 and IFNGR2. [ 2 ] [ 3 ] In unstimulated cells, these subunits are not preassociated with each other but rather associate through their intracellular domains with inactive forms of specific Janus family kinases (Jak1 and Jak2).
They include interleukin-1 (IL-1), IL-6, IL-12, and IL-18, tumor necrosis factor alpha (TNF-α), interferon gamma (IFNγ), and granulocyte-macrophage colony stimulating factor (GM-CSF) and play an important role in mediating the innate immune response. Inflammatory cytokines are predominantly produced by and involved in the upregulation of ...
He later won the Nobel Prize in chemistry. Interferon was scarce and expensive until 1980, when the interferon gene was inserted into bacteria using recombinant DNA technology, allowing mass cultivation and purification from bacterial cultures [84] or derived from yeasts. Interferon can also be produced by recombinant mammalian cells. [85]
Whole-person specialty care, a model where a comprehensive care team works together to coordinate personalized and individualized treatment, is offering renewed hope for patients.
3440 15965 Ensembl ENSG00000188379 ENSMUSG00000078354 UniProt P01563 P01573 RefSeq (mRNA) NM_000605 NM_010503 RefSeq (protein) NP_000596 NP_034633 Location (UCSC) Chr 9: 21.38 – 21.39 Mb Chr 4: 88.6 – 88.6 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene. Protein family Human interferon alpha-2 (IFNα2) is ...
This article was reviewed by Craig Primack, MD, FACP, FAAP, FOMA. Zone 2 training is a type of cardio exercise where you use your heart rate as a guide to help you find the right intensity for ...