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A wound is any disruption of or damage to living tissue, such as skin, mucous membranes, or organs. [1] [2] Wounds can either be the sudden result of direct trauma (mechanical, thermal, chemical), or can develop slowly over time due to underlying disease processes such as diabetes mellitus, venous/arterial insufficiency, or immunologic disease. [3]
Major trauma is a severe traumatic injury that has the potential to cause disability or death. Serious traumatic injury most often occurs as a result of traffic collisions. [11] Traumatic injury is the leading cause of death in people under the age of 45. [12] Blunt trauma injuries are caused by the forceful impact of an external object.
Timing is important to wound healing. Critically, the timing of wound re-epithelialization can decide the outcome of the healing. [11] If the epithelization of tissue over a denuded area is slow, a scar will form over many weeks, or months; [12] [13] If the epithelization of a wounded area is fast, the healing will result in regeneration.
This injury has also been reported in babies younger than six months and in older children up to the preteen years. There is a slight predilection for this injury to occur in girls and in the left arm. The classic mechanism of injury is longitudinal traction on the arm with the wrist in pronation, as occurs when the child is lifted up by the wrist.
The pathophysiology of obesity involves many possible pathophysiological mechanisms involved in its development and maintenance. [25] [26] This field of research had been almost unapproached until the leptin gene was discovered in 1994 by J. M. Friedman's laboratory. [27] These investigators postulated that leptin was a satiety factor.
There was a significant mechanism of injury (for example, a high-speed car accident, falls >20 ft); OR; The patient has an altered mental status; OR; The medical responder suspects that the patient has multi-systems trauma; If NONE of these criteria are met, the medical provider may go through a slower or more focused trauma assessment. [3]
Injury is physiological damage to the living tissue of any organism, whether in humans, in other animals, or in plants. Injuries can be caused in many ways, including mechanically with penetration by sharp objects such as teeth or with blunt objects , by heat or cold, or by venoms and biotoxins .
Mechanism of injury (MOI) is the means by which an injury occurs. [2] It is important because in the absence of an MoI there is no hazard. Common mechanisms of injury are "slips, trips and falls", for example: Hazard: Ex. a tool bag (in walkway) Mechanism of injury: Ex. trip (over tool bag) Injury = Bone fracture; Other common mechanisms of ...