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The direct Coombs test is used to test for autoimmune hemolytic anemia, a condition where the immune system breaks down red blood cells, leading to anemia. The direct Coombs test is used to detect antibodies or complement proteins attached to the surface of red blood cells. To perform the test, a blood sample is taken and the red blood cells ...
It detects antibodies bound to the surface of red blood cells in vivo. The red blood cells (RBCs) are washed (removing the patient's own plasma) and then incubated with antihuman globulin (also known as "Coombs reagent"). If this produces agglutination of the RBCs, the direct Coombs test is positive. The indirect Coombs test is used in prenatal ...
Robert Royston Amos Coombs (9 January 1921 – 25 January 2006) [1] was a British immunologist, co-discoverer of the Coombs test (1945) used for detecting antibodies in various clinical scenarios, such as Rh disease and blood transfusion.
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Traumatic hemolytic anemia [2]. Impact [2]; Macrovascular defects-prostheses [2]; Microvascular causes [2]. Disseminated intravascular hemolysis [2]; Thrombotic thrombocytopenic purpura [2]
A laboratory test, the direct Coombs test, is used to detect these antibodies or complement proteins that are bound to the surface of red blood cells; a blood sample is taken and the RBCs are washed (removing the patient's own plasma) and then incubated with antihuman globulin (also known as "Coombs reagent").
Routine tests in the first trimester of pregnancy generally include: Complete blood count; Blood type. Rh-negative antenatal patients should receive RhoGAM at 28 weeks to prevent Rh disease. Indirect Coombs test (AGT) to assess risk of hemolytic disease of the newborn [5] Rapid plasma reagin test to screen for syphilis; Rubella antibody screen [6]
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