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[11] [12] [129] A formulation of MPA as an aqueous suspension for subcutaneous injection is also available in the United States under the brand name Depo-SubQ Provera 104. [ 11 ] [ 12 ] Other brand names of MPA formulated alone include Farlutal and Sayana for clinical use and Depo-Promone, Perlutex, Promone-E, and Veramix for veterinary use.
Depot MPA (DMPA) and EC/MPA were developed by Upjohn in the 1960s. [12] [13] DMPA (brand name Depo-Provera) was introduced for use as a progestogen-only injectable contraceptive for the first time outside of the United States in 1969 and was subsequently approved for use in birth control in the United States in 1992.
The half-progestin-dose formulation of estradiol valerate/norethisterone enantate (5 mg / 25 mg) is also known as HRP-103 and the half-progestin-dose formulation of estradiol cypionate/medroxyprogesterone acetate (5 mg / 12.5 mg) is also known as HRP-113. [63] The following are CICs that have never been marketed:
A third combined injection, Cyclo-Provera, was reformulated in the 1980s by lowering the dose and renamed Cyclofem (also called Lunelle). Cyclofem and Mesigyna, another formulation developed in the 1980s, were approved by the World Health Organization in 1993. [59] NuvaRing, a contraceptive vaginal ring, was first marketed in 2002.
They can come in formulations such as pills, vaginal rings, and transdermal patches. [15] Most people who use combined hormonal contraception experience breakthrough bleeding within the first 3 months. [15] Other common side effects include headaches, breast tenderness, and changes in mood. [16]
[1] [2] Other side effects of progestogens may include an increased risk of breast cancer, cardiovascular disease, and blood clots. [2] At high doses, progestogens can cause low sex hormone levels and associated side effects like sexual dysfunction and an increased risk of bone fractures .
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