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Mirtazapine is sometimes described as a noradrenergic and specific serotonergic antidepressant (NaSSA), [11] although the actual evidence in support of this label has been regarded as poor. [17] It is a tetracyclic piperazine-azepine. [85] Mirtazapine has antihistamine, α 2-blocker, and antiserotonergic activity.
Chemical structure of the prototypical NaSSA mirtazapine (original brand name Remeron). Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1]
Besides mirtazapine, they also block the α 1-adrenergic receptor [citation needed]. Conversely, whereas TCAs have relatively low affinity for the α 2 -adrenergic receptor , mianserin and mirtazapine potently antagonize this receptor, and this action is thought to be involved in their antidepressant effects [ citation needed ] .
Veronica Brown lived with chronic fatigue, depression, and anxiety for over 10 years before she learned they were early signs of Parkinson's disease. Here's how she found relief after diagnosis.
But sundowning has some unique signs that make it stand out from just being tired. “Fatigue can occur at all times of the day. Sundowning is truly confusion,” Dr. Kobylarz says. “If you have ...
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My anxiety would be even worse in the mornings if I overexerted myself the night before, from having too many social plans, a busy day at work or too much to drink. Silke Woweries
This type of sleep disorder may make it harder to fall and stay asleep at night than during the day. Hypersomnia is often associated with atypical depression as well as seasonal affective disorder. [8] A general lack of energy, fatigue, and tiredness that cannot be otherwise explained is also a symptom of a major depressive episode. [3]