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Gout (/ É¡ aÊŠ t / GOWT [7]) is a form of inflammatory arthritis characterized by recurrent attacks of pain in a red, tender, hot, and swollen joint, [2] [8] caused by the deposition of needle-like crystals of uric acid known as monosodium urate crystals. [9] Pain typically comes on rapidly, reaching maximal intensity in less than 12 hours. [5]
The presence of uric acid crystals in joint tissue is what leads to the inflammation and pain associated with gout. Levels of uric acid can rise for different things. For instance, due to genetic ...
Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease, also known as pseudogout and pyrophosphate arthropathy, is a rheumatologic disease which is thought to be secondary to abnormal accumulation of calcium pyrophosphate dihydrate crystals within joint soft tissues. [1] The knee joint is most commonly affected. [2]
Uric acid displays lactam–lactim tautomerism. [4] Uric acid crystallizes in the lactam form, [5] with computational chemistry also indicating that tautomer to be the most stable. [6] Uric acid is a diprotic acid with pK a1 = 5.4 and pK a2 = 10.3. [7] At physiological pH, urate predominates in solution. [medical citation needed]
Uric acid forms crystals around joints in the body, most commonly in the big toe or knee, but can be found in any joint. When this occurs, the affected joint results in severe pain, swelling and ...
Analysis of a sample of synovial fluid to look for signs of an infection (infectious arthritis) or uric acid crystals (gout) Imaging tests, such as X-rays or MRI scans, to evaluate the condition ...
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