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  2. Sickle cell disease - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_disease

    Base-pair substitution that causes sickle cell anemia. The gene defect is a single nucleotide mutation of the β-globin gene, which results in glutamate being substituted by valine at position 6 of the β-globin chain. [62] Hemoglobin S with this mutation is referred to as HbS, as opposed to the normal adult HbA.

  3. Hemoglobin D - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_D

    Individuals have normal hemoglobin level and their red blood cells are normal spherical structure. [29] Homozygous HbD/HbD causes mild hemolytic anemia and chronic non-progressive splenomegaly (enlargement of spleen). [4] Heterozygous HbD/HbS causes sickle cell anemia. However, most cases of the disease are milder than the usual HbS/HbS conditions.

  4. Anemia - Wikipedia

    en.wikipedia.org/wiki/Anemia

    [31] [32] Other specific causes of anemia may have signs and/or complications such as, jaundice with the rapid break down of red blood cells as with hemolytic anemia, bone abnormalities with thalassemia major, or leg ulcers as seen in sickle cell disease. In severe anemia, there may be signs of a hyperdynamic circulation: tachycardia (a fast ...

  5. Woman to Woman: Causes, symptoms and treatments of sickle ...

    www.aol.com/woman-woman-causes-symptoms...

    NEW HAVEN, Conn. (WTNH) — Sickle cell disease is an inherited blood disorder impacting 100,000 people in the U.S., disproportionately people of color. Dr. Lila Van Doren, assistant professor of ...

  6. Sickle cell trait - Wikipedia

    en.wikipedia.org/wiki/Sickle_cell_trait

    Athletes with sickle cell trait and their instructors must be aware of the dangers of the condition during anaerobic exertion especially in hot and dehydrated conditions. [25] In rare cases, exercise-induced dehydration or exhaustion may cause healthy red blood cells to turn sickle-shaped, which can cause death during sporting activities. [26]

  7. FDA considers first CRISPR gene editing treatment that may ...

    www.aol.com/fda-considers-first-crispr-gene...

    With sickle cell disease — also called sickle cell anemia — red blood cells take on a folded or sickle shape that can clog tiny blood vessels and cause progressive organ damage and pain, and ...

  8. Congenital hemolytic anemia - Wikipedia

    en.wikipedia.org/wiki/Congenital_hemolytic_anemia

    The underlying cause of sickle cell anemia is the synthesis of aberrant hemoglobin, which attaches to other aberrant hemoglobin molecules inside the red blood cell to undergo rigid deformation. [18] Sickle cell anemia symptoms usually appear around the age of six months. They can change over time and differ from person to person.

  9. Hemoglobin C - Wikipedia

    en.wikipedia.org/wiki/Hemoglobin_C

    HbC can combine with other abnormal hemoglobins and cause serious hemoglobinopathies. Individuals with sickle cell–hemoglobin C (HbSC), have inherited the gene for sickle cell disease (HbS) from one parent and the gene for hemoglobin C disease (HbC) from the other parent. Since HbC does not polymerize as readily as HbS, there is less sickling ...

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