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Ferritin is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. Plasma ferritin is also an indirect marker of the total amount of iron stored in the body; hence, serum ferritin is used as a diagnostic test for iron-deficiency anemia and iron overload. [4]
Hemosiderin is also generated from the abnormal metabolic pathway of ferritin. [3] It is only found within cells (as opposed to circulating in blood) and appears to be a complex of ferritin, denatured ferritin and other material. [4] [5] The iron within deposits of hemosiderin is very poorly available to supply iron when needed.
Hemosiderinuria (syn. haemosiderinuria) is the presence of hemosiderin in urine. [1] It is often the result of chronic intravascular hemolysis, in which hemoglobin is released from red blood cells into the bloodstream in excess of the binding capacity of haptoglobin. The function of haptoglobin is to bind to circulating hemoglobin, thereby ...
The interpretation of urinalysis takes into account the results of physical, chemical and microscopic examination and the person's overall condition. Urine test results should always be interpreted using the reference range provided by the laboratory that performed the test, or using information provided by the test strip/device manufacturer. [136]
Just received your urine test results? This is why white blood cells are present, these are the possible causes...
Kidneys are important for regulating blood pressure and filtering waste products from the bloodstream; managing urine excretion to prevent dehydration; and regulating levels of electrolytes and ...
In urine cytology, collected urine is examined microscopically. One limitation, however, is the inability to definitively identify low-grade cancer cells and urine cytology is used mostly to identify high-grade tumors. [4] If the test detects atypical or cancerous cells, further tests may be recommended, such as cystoscopy and a CT scan.
In histology, histopathology, and clinical pathology, Perls Prussian blue is a commonly used method to detect the presence of iron in tissue or cell samples. [ 1 ] : 235 [ 2 ] [ 3 ] [ 4 ] Perls Prussian Blue derives its name from the German pathologist Max Perls (1843–1881), who described the technique in 1867. [ 2 ]
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