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For the treatment of simple cystitis in children, a five-day oral course of cephalexin is the preferred choice. As for children with suspected pyelonephritis, a ten-day treatment regimen is recommended. In such cases, a third-generation cephalosporin, such as cefdinir, is suggested as an appropriate option.
Among children, urinary tract infections are most common in uncircumcised males less than three months of age, followed by females less than one year. [28] Estimates of frequency among children, however, vary widely. In a group of children with a fever, ranging in age between birth and two years, 2–20% were diagnosed with a UTI. [28]
Pyelonephritis affects about 1 to 2 per 1,000 women each year and just under 0.5 per 1,000 males. [5] [7] Young adult females are most often affected, followed by the very young and old. [2] With treatment, outcomes are generally good in young adults.
Nitrofurantoin is not recommended for the treatment of pyelonephritis (kidney infection), [24] and intra-abdominal abscess, [29] because of extremely poor tissue penetration and low blood levels. [16] [21] Nitrofurantoin appears likely to minimally penetrate the prostate gland.
[4] [6] [7] It can be used in children and those over 65 years of age. [4] Those with kidney problems may require a decrease in dose. [4] Cefalexin was developed in 1967. [8] [9] [10] It was first marketed in 1969 under the brand name Keflex. [11] [12] It is available as a generic medication.
Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cephalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacterium Streptococcus pyogenes, causing the disease popularly called strep throat or streptococcal tonsillitis, urinary tract infection, reproductive tract infection, and skin infections.
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Cefepime/enmetazobactam, sold under the brand name Exblifep, is a medication used for the treatment of urinary tract infections. [1] [2] It is a fixed dose combination containing cefepime, a cephalosporin antibacterial; and enmetazobactam, a beta-lactamase inhibitor.
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