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The antidotes for ethylene glycol poisoning are ethanol and fomepizole. This antidotal treatment forms the mainstay of management of ethylene glycol poisoning. The toxicity of ethylene glycol comes from its metabolism to glycolic acid and oxalic acid. The goal of pharmacotherapy is to prevent the formation of these metabolites.
Ethylene glycol, antifreeze, is extremely toxic to dogs. It has a sweet taste and thus dogs will drink it. As little as 2 1/2 tablespoons can kill a medium-sized dog in 2–3 days. This type of poisoning is often fatal as dog owners do not know their pet has ingested the antifreeze. De-icing fluids can also contain ethylene glycol.
The effect of ethanol on dogs and cats is similar to its effect on humans, also causing intoxication. Death is unlikely given supportive care (only one death is known). Ethanol is also an antidote for ethylene glycol poisoning. [47] Mouse and rat poison, anticoagulant type Rodenticide is commonly found in the house or garage.
6. Worms and other parasitic infections. With heavy worm burdens or certain parasitic infections, dogs can vomit. You may see worms in the vomit, but an absence of worms doesn’t mean parasites ...
The dog then causes further trauma to the skin by itching and rubbing at the area, leading to a secondary bacterial infection." Acute moist dermatitis: Symptoms A patch of moist, inflamed skin ...
Fomepizole is used to treat ethylene glycol and methanol poisoning. It acts to inhibit the breakdown of these toxins into their active toxic metabolites. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase, [6] found in the liver. This enzyme plays a key role in the metabolism of ethylene glycol, and of methanol.
Frostbite in dogs is a serious condition. It occurs when the skin and underlying tissues are exposed to freezing or extremely cold temperatures for a prolonged period of time.
An antidote is a substance that can counteract a form of poisoning. [1] ... Isoniazid poisoning, ethylene glycol, accidental hydrazine exposure ...
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