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However, triamcinolone acetonide has 15% of the affinity of progesterone for the progesterone receptor. [23] In relation to this, triamcinolone acetonide can produce endocrine side effects like ovulation inhibition and menstrual irregularities. [24] [25] [26]
The derivative triamcinolone acetonide is the active ingredient in various topical skin preparations (cream, lotion, ointment, aerosol spray) designed to treat skin conditions such as rash, inflammation, redness, or intense itching due to eczema [15] and dermatitis. [16]
Side effects may occur from sudden discontinuation and prolonged, ... (Aclovate cream, ointment) Triamcinolone acetonide 0.025% (Aristocort A cream, Kenalog lotion)
In general, use a potent preparation short term and weaker preparation for maintenance between flare-ups. While there is no proven best benefit-to-risk ratio, [11] if prolonged use of a topical steroid on a skin surface is required, a pulse therapy should be undertaken.
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Even low-potency topical glucocorticoids are able to cause adverse effects in children when used for prolonged periods of time. Generally, a smaller dose of topical glucocorticoid is required by children for a given condition than adults, as children have relatively smaller body surface area compared to adults.
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In the context of glucocorticoids, potency is generally a quantitative notion referring to the dose required to produce a useful anti-inflammatory effect, so that a smaller dose of a more potent drug (e.g. dexamethasone) is approximately equivalent, in both its therapeutic and side effects, to a larger dose of a less potent drug (e.g. prednisone).