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In response to interferon, cells produce large amounts of an enzyme known as protein kinase R (PKR). This enzyme phosphorylates a protein known as eIF-2 in response to new viral infections; the phosphorylated eIF-2 forms an inactive complex with another protein, called eIF2B, to reduce protein synthesis within
3456 15977 Ensembl ENSG00000171855 ENSMUSG00000048806 UniProt P01574 P01575 RefSeq (mRNA) NM_002176 NM_010510 RefSeq (protein) NP_002167 NP_034640 Location (UCSC) Chr 9: 21.08 – 21.08 Mb Chr 4: 88.44 – 88.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon beta is a protein that in humans is encoded by the IFNB1 gene. The natural and recombinant protein forms have ...
Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein kinase, or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 gene on chromosome 2. [5] [6] PKR is a serine/tyrosine kinase that is 551 amino acids ...
3440 15965 Ensembl ENSG00000188379 ENSMUSG00000078354 UniProt P01563 P01573 RefSeq (mRNA) NM_000605 NM_010503 RefSeq (protein) NP_000596 NP_034633 Location (UCSC) Chr 9: 21.38 – 21.39 Mb Chr 4: 88.6 – 88.6 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene. Protein family Human interferon alpha-2 (IFNα2) is ...
The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses. In the human genome, a cluster of thirteen functional IFN genes is located at the 9p21.3 cytoband over approximately 400 kb including coding genes for IFNα (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16 ...
Gamma-interferon-inducible lysosomal thiol reductase is an enzyme that, in humans, is encoded by the IFI30 gene. [5] [6] [7] The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in ...
The longtime college football commentator has little use for Indiana's undefeated record, given its schedule.
n/a Ensembl ENSG00000197919 n/a UniProt P01562 n/a RefSeq (mRNA) NM_024013 n/a RefSeq (protein) NP_076918 n/a Location (UCSC) Chr 9: 21.44 – 21.44 Mb n/a PubMed search n/a Wikidata View/Edit Human Interferon alpha-1 is a protein that in humans is encoded by the IFNA1 gene. Leukocyte interferon is produced predominantly by B lymphocytes. Immune interferon (IFN-gamma ; MIM 147570) is produced ...