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Azelaic acid is used for treatment of skin pigmentation, including melasma and postinflammatory hyperpigmentation, particularly in those with darker skin types. It has been recommended as an alternative to hydroquinone. [23] As a tyrosinase inhibitor, [5] azelaic acid reduces synthesis of melanin. [24]
Hyperpigmentation is believed to be related to the enzyme tyrosinase which produces melanin. Among several chemicals known to inhibit tyrosinase production, such as hydroquinone, arbutin, and kojic acid, 4-butylresorcinol has been found to be the most powerful inhibitor by a wide margin.
This toner takes skin-brightening to the next level by pairing kojic acid with vitamin C — yet another tyrosinase inhibitor — as well as bearberry extract, a plant-based alternative to ...
Your doctor may suggest taking a low dose of melatonin because it inhibits tyrosinase (an enzyme in our skin that helps produce melanin), reducing pigment production, says Dr. Charles. Dr.
Tyrosinase is an enzyme needed in melanin synthesis in the melanin producing cell of the skin, the melanocyte. By reducing the activity of tyrosinase, β-arbutin reduces the synthesis of melanin, leading to a lighter skin tone and the diminished appearance of hyperpigmentation. It is not as potent an inhibitor of tyrosinase as α-arbutin. [6]
Mela B3 Dark Spot Serum. Over 18 years of research went into La Roche-Posay's Dark Spot Serum and its patented ingredient, melsyl, which targets discoloration while respecting the skin's natural tone.
Tyrosinase is a highly conserved protein in animals and apparently arose already in bacteria. The tyrosinase related protein (Tyrp1) and dopachrome tautomerase (Dtc), which encode for protein implicated in melanin synthesis which are the common regulatory elements of exon/intron structure.
It may sound like chemistry soup, but, according to Dr. Diana Howard, vice president of research and development and global education for Dermalogica, niacinamide is the next BIG skin-care ...
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