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  2. Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Parkinson's_disease

    Parkinson's disease (PD), or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor and non-motor systems. Symptoms typically develop gradually, with non-motor issues becoming more prevalent as the disease progresses.

  3. Signs and symptoms of Parkinson's disease - Wikipedia

    en.wikipedia.org/wiki/Signs_and_symptoms_of...

    Parkinson's Disease causes constipation and gastric dysmotility that is severe enough to endanger comfort and even health. [26] A factor in this is the appearance of Lewy bodies and Lewy neurites even before these affect the functioning of the substantia nigra in the neurons in the enteric nervous system that control gut functions.

  4. Parkinsonism - Wikipedia

    en.wikipedia.org/wiki/Parkinsonism

    Parkinsonism is a clinical syndrome characterized by the four motor symptoms found in Parkinson's disease: tremor, bradykinesia (slowed movements), rigidity, and postural instability. [ 1 ] [ 2 ] Parkinsonism gait problems can lead to falls and serious physical injuries.

  5. Post-encephalitic parkinsonism - Wikipedia

    en.wikipedia.org/wiki/Post-encephalitic_parkinsonism

    Post-encephalitic parkinsonism is a disease believed to be caused by a viral illness that triggers degeneration of the nerve cells in the substantia nigra. Overall, this degeneration leads to clinical parkinsonism.

  6. Parkinson's disease and gut-brain axis - Wikipedia

    en.wikipedia.org/wiki/Parkinson's_Disease_and_Gut...

    Parkinson's disease (PD), the second most common neurodegenerative disease after Alzheimer's disease, affects 1% of people over 60 years of age. [1] [2] [3] In the past three decades, the number of PD cases has doubled globally from 2.5 million in 1990 to 6.1 million in 2016. [4] [5] As of 2022, there are ~10 million PD cases globally. [6]

  7. Extrapyramidal symptoms - Wikipedia

    en.wikipedia.org/wiki/Extrapyramidal_symptoms

    Although Parkinson's disease is primarily a disease of the nigrostriatal pathway and not the extrapyramidal system, loss of dopaminergic neurons in the substantia nigra leads to dysregulation of the extrapyramidal system. Since this system regulates posture and skeletal muscle tone, a result is the characteristic bradykinesia of Parkinson's.

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